Dimethylamine → HCID 46901758, compound

HRID 217805Notes

Reaction equation

HRID 217805 reaction equation
Cl[C:2]1[N:7]=[C:6]2[N:8]=[CH:9][CH:10]=[C:11]([O:12][C:13]3[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[C:15]([F:27])[CH:14]=3)[C:5]2=[N:4][CH:3]=1.[CH3:28][NH:29][CH3:30]>>[CH3:28][N:29]([CH3:30])[C:2]1[N:7]=[C:6]2[N:8]=[CH:9][CH:10]=[C:11]([O:12][C:13]3[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[C:15]([F:27])[CH:14]=3)[C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 46899947HCID 46899947, compound

Product 1

HCID 46901758HCID 46901758, compound

Procedure

Method D6 was used with tert-butyl 4-(3-chloropyrido[2,3-b]pyrazin-8-yloxy)-2-fluorophenylcarbamate (270 mg, 0.67 mmol) and dimethylamine to give the product as a yellow solid. Yield: 233 mg (91%).

Sources & evidence

ORD record
ord-ff6da1e088254dc982611653cac3cdfc
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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