Ethyl 3-oxo-3-(pyridin-3-yl)-2-(thiophen-3-yl)propanoate → 1-(Pyridin-3-yl)-2-(thiophen-3-yl)ethanone

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-oxo-3-(pyridin-3-yl)-2-(thiophen-3-yl)propanoate (2 g, 7.26 mmol) in DMSO (20 mL) was added catalytic amount of brine (0.2 mL). The reaction mixture was heated at 160° C. for 2 h. The reaction mixture was cooled to room temperature, diluted with water, and extracted with EtOAc. The organic layer was concentrated in vacuo and purified by column chromatography to afford Intermediate 56 (1 g, yield 68%).

Provenance & Evidence