3-tert-Butyl-5-isocyanato-1-p-tolyl-1H-pyrazole → 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

HRID 217808Notes

Reaction equation

HRID 217808 reaction equation
[O:1]=[C:2]1[NH:7][C:6]2[N:8]=[CH:9][CH:10]=[C:11]([O:12][C:13]3[CH:18]=[CH:17][C:16]([NH:19][C:20](=O)[O:21]C(C)(C)C)=[CH:15][CH:14]=3)[C:5]=2[N:4]=[CH:3]1.[C:27]([C:31]1[CH:35]=[C:34]([N:36]=C=O)[N:33]([C:39]2[CH:44]=[CH:43][C:42]([CH3:45])=[CH:41][CH:40]=2)[N:32]=1)([CH3:30])([CH3:29])[CH3:28]>>[C:27]([C:31]1[CH:35]=[C:34]([NH:36][C:20]([NH:19][C:16]2[CH:15]=[CH:14][C:13]([O:12][C:11]3[C:5]4[N:4]=[CH:3][C:2](=[O:1])[NH:7][C:6]=4[N:8]=[CH:9][CH:10]=3)=[CH:18][CH:17]=2)=[O:21])[N:33]([C:39]2[CH:40]=[CH:41][C:42]([CH3:45])=[CH:43][CH:44]=2)[N:32]=1)([CH3:30])([CH3:29])[CH3:28]

Participants

3

Reactant 2

HCID 179878553-tert-Butyl-5-isocyanato-1-p-tolyl-1H-pyrazoleHCID 46900574Tert-butyl 4-(3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenylcarbamate

Product 1

HCID 441339061-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)ureaYield 55%

Procedure

Method F1 was used with Tert-butyl 4-(3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenylcarbamate and 3-tert-butyl-5-isocyanato-1-p-tolyl-1H-pyrazole to obtain the title compound (yield 55%).

Sources & evidence

ORD record
ord-d13ebafebb854877bef1a6732cc5a51c
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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