HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2178090Generated: October 31, 2026
Methyl 2-chloro-4-(hydroxymethyl)benzoate → Methyl 2-chloro-4-formylbenzoate
https://huagongshe.com/reaction/2178090
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 2-chloro-4-(hydroxymethyl)benzoate | HCID 19780655 | — |
| Catalyst | Manganese oxide | HCID 160959 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-chloro-4-formylbenzoate | HCID 57461225 | 62.2% |
Reaction Steps
A mixture of methyl 2-chloro-4-(hydroxymethyl)benzoate (350 mg, 1.7 mmol) in and manganese oxide (756 mg, 30.9 mmol) in dichloromethane (10 mL) was stirred at 27° C. for 6 hours. The mixture was filtered and evaporated in vacuo to give Intermediate 75 (210 mg, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09067893B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-c50c1a8049f24f3f9d5a9c6552ef9277 |
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| Source note | uspto-grants-2015_06 |
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