HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzonitrile, 2,6-dichloro-4-hydroxy- → 3-cyano-4-(3,5-dichloro-4-cyanophenoxy)-N-(5-fluoropyridin-2-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzonitrile, 2,6-dichloro-4-hydroxy- | HCID 18747 | — |
| Reactant | 3-cyano-N-(2,4-di methoxybenzyl)-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamide | HCID 117653362 | — |
| Product | 3-cyano-4-(3,5-dichloro-4-cyanophenoxy)-N-(5-fluoropyridin-2-yl)benzenesulfonamide | HCID 117653461 | — |
Reaction Steps
The title compound was prepared according to the method described for Method Variation 5 using 3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamide (Preparation 18) and 2,6-dichloro-4-hydroxybenzonitrile, and then purified using preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067922B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-644540869c6645bca721c1e504ec3f61 |
| Source note | uspto-grants-2015_06 |