3-Cyano-4-fluorobenzenesulfonyl chloride → HCID 117653431, compound

HRID 2178133Notes

Reaction equation

HRID 2178133 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:4]=1[CH2:5][NH:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][N:14]=1)[C:10]#[N:11].[C:21]([C:23]1[CH:24]=[C:25]([S:30](Cl)(=[O:32])=[O:31])[CH:26]=[CH:27][C:28]=1[F:29])#[N:22]>>[C:21]([C:23]1[CH:24]=[C:25]([S:30]([N:6]([C:7]2[CH:8]=[C:9]([C:10]#[N:11])[CH:12]=[CH:13][N:14]=2)[CH2:5][C:4]2[CH:15]=[CH:16][C:17]([O:19][CH3:20])=[CH:18][C:3]=2[O:2][CH3:1])(=[O:32])=[O:31])[CH:26]=[CH:27][C:28]=1[F:29])#[N:22]

Participants

3

Reactant 2

HCID 27789083-Cyano-4-fluorobenzenesulfonyl chlorideHCID 63363218HCID 63363218, compound

Product 1

HCID 117653431HCID 117653431, compound

Procedure

The title compound was prepared according to the method described for Preparation 18 using 2-((2,4-dimethoxybenzyl)amino)isonicotinonitrile (Preparation 35) and 3-cyano-4-fluorobenzene-1-sulfonyl chloride. The residue was purified by reverse phase chromatography eluting with 0-100% MeCN in water/0.1% formic acid.

Workup

  1. customThe residue was purified by reverse phase chromatography
  2. washeluting with 0-100% MeCN in water/0.1% formic acid

Sources & evidence

ORD record
ord-fb7a3c207cdb4c829b6848534629c774
Source dataset
uspto-grants-2015_06
Patent number
US09067922B2

Reaction notes

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