3,3,3-Trifluoropropene → HCID 71662965, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3,3,3-trifluoroprop-1-ene (ca. 4.3 g, 45 mmol) in AcOEt (30 ml) and sodium bicarbonate (6.3 g, 75.0 mmol) was added at −78° C. a solution of (Z)-ethyl 2-chloro-2-(hydroxyimino)acetate (2.81 g, 18.0 mmol) in AcOEt (6 ml), the suspension was allowed to warm to 22° C. and stirring was continued for 60 h. The suspension was filtered, the filtrate was evaporated and the residue purified by chromatography on silica gel using heptane/AcOEt (10:1) to give ethyl 5-(trifluoromethyl)-4,5-dihydroisoxazole-3-carboxylate (3.2 g) as a colorless oil. MS: m/z=211 [M]+.

Provenance & Evidence