HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoromethoxypyridine-2-carboxylic acid → N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoromethoxypyridine-2-carboxylic acid | HCID 57475870 | — |
| Reactant | (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine | HCID 71663148 | — |
| Product | N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)picolinamide | HCID 71667599 | — |
Reaction Steps
The coupling of (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (XI-1) and 5-(fluoromethoxy)picolinic acid [CAS 1174321-03-9; J. M. Ellard et al. WO2011009898 (2011)] following General Procedure F yielded the title compound as a colorless solid. MS: m/z=445.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067926B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-651f6c7d4ca545a6a8c45ea528ada3b1 |
| Source note | uspto-grants-2015_06 |