HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyano-3-methylpyridine-2-carboxylic acid → N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyano-3-methylpyridine-2-carboxylic acid | HCID 66665846 | — |
| Reactant | (4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine | HCID 86732112 | — |
| Product | N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide | HCID 71668047 | — |
Reaction Steps
The coupling of (4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (XI-2) and 5-cyano-3-methylpicolinic acid [S. Badiger et al. WO2011009943 (2011)] following General Procedure G yielded the title compound as a light yellow solid. MS: m/z=454.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067926B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-a57a6c7affff4baaa6e2cfe2fe374f27 |
| Source note | uspto-grants-2015_06 |