Trifluoroacetic acid → HCID 86670225, compound

Participants

Reaction Steps

A solution of N-[rel-(S)-1-((3S,4R)-4-cyanomethylsulfanyl-tetrahydro-furan-3-yl)-1-(2-fluoro-phenyl)-ethyl]-N-(2,4-dimethoxy-benzyl)-2,2,2-trifluoro-acetamide (1.65 g, 3.13 mmol) in trifluoroacetic acid (14.5 ml, 188 mmol) was stirred at room temperature overnight. The reaction mixture was extracted with a mixture of a saturated solution of sodium hydrogencarbonate and ethyl acetate/tetrahydrofuran. The combined organic layers were dried over sodium sulphate and evaporated at reduced pressure. The crude N-[rel-(S)-1-((3S,4R)-4-cyanomethylsulfanyl-tetrahydro-furan-3-yl)-1-(2-fluoro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide was obtained as a white solid and engaged in the following step without further purification. MS (ISP): m/z=375.3 [M+H]+.

Provenance & Evidence