反应详情

To a solution of ethyl 3-bromo-6-chloro-2-oxohexanoate (23A) (0.845 g, 3.11 mmol) in acetone (6 mL) was added thiourea (0.284 g, 3.73 mmol) and refluxed overnight. The reaction mixture was concentrated under reduced pressure. EtOAc and hexanes in a ratio of 1:9 was added and stirred for 1 hour. Added acetone to dissolve material and concentrated under reduced pressure to give 0.718 g (93%) of the desired product ethyl 2-amino-5-(3-chloropropyl)thiazole-4-carboxylate (23B): LC/MS (APCI): m/z 249.5 (M+H).

1. temperaturerefluxed overnight
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additionEtOAc and hexanes in a ratio of 1:9 was added
4. dissolutionAdded acetone to dissolve material
5. concentrationconcentrated under reduced pressure