2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → HCID 44133363, compound

HRID 217823Notes

Reaction equation

HRID 217823 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N:12]=[C:13]=[O:14].[NH2:15][C:16]1[CH:34]=[CH:33][C:19]([O:20][C:21]2[C:26]3=[N:27][CH:28]=[C:29]([NH:31][CH3:32])[N:30]=[C:25]3[N:24]=[CH:23][CH:22]=2)=[CH:18][C:17]=1[F:35]>>[F:35][C:17]1[CH:18]=[C:19]([O:20][C:21]2[C:26]3=[N:27][CH:28]=[C:29]([NH:31][CH3:32])[N:30]=[C:25]3[N:24]=[CH:23][CH:22]=2)[CH:33]=[CH:34][C:16]=1[NH:15][C:13]([NH:12][C:3]1[CH:4]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:7][C:2]=1[F:1])=[O:14]

Participants

3

Reactant 2

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 46901904HCID 46901904, compound

Product 1

HCID 44133363HCID 44133363, compound

Procedure

Method F2 was used with 2-fluoro-5-(trifluoromethyl)phenyl isocyanate and 8-(4-amino-3-fluorophenoxy)-N-methylpyrido[3,2-b]pyrazin-3-amine to give the title compound as a white solid. Yield: 56 mg (80%).

Sources & evidence

ORD record
ord-cbe4bcbf428a44b3951b8bb8943ecb47
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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