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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 217824Generated: October 29, 2026

3-tert-Butyl-5-isocyanato-1-phenyl-1H-pyrazole → 1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-methyl-2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

https://huagongshe.com/reaction/217824

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-tert-Butyl-5-isocyanato-1-phenyl-1H-pyrazoleHCID 11096760—
Reactant8-(4-Amino-3-fluorophenoxy)-3-methylpyrido[2,3-b]pyrazin-2(1H)-oneHCID 46901248—
Product1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-methyl-2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)ureaHCID 44133545—

Reaction Steps

Method F3 was used with 3-tert-butyl-5-isocyanato-1-phenyl-1H-pyrazole and 8-(4-Amino-3-fluorophenoxy)-3-methylpyrido[2,3-b]pyrazin-2(1H)-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08198279B2
Source datasetuspto-grants-2012_06
ORD IDord-3e6a96749c7e4fe4ba279859950c7bb2
Source noteuspto-grants-2012_06