HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 2-(indolin-6-yl)thiazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl 2-(1-(tert-butoxycarbonyl)indolin-6-yl)thiazole-4-carboxylate | HCID 59418726 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 2-(indolin-6-yl)thiazole-4-carboxylate | HCID 59418774 | 170.1% |
Reaction Steps
To ethyl 2-(1-(tert-butoxycarbonyl)indolin-6-yl)thiazole-4-carboxylate (28C) (46 mg, 0.12 mmol) was added DCM (5 ml) and TFA (1 ml) and stirred for 2.5 hours. The mixture was concentrated under reduced pressure to provide 56 mg of the desired product ethyl 2-(indolin-6-yl)thiazole-4-carboxylate (28D): LC/MS (APCI): m/z 275.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067928B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-16d9d43ae4214cdc93a6dc34eb871de6 |
| Source note | uspto-grants-2015_06 |