3-tert-Butyl-5-isocyanato-1-phenyl-1H-pyrazole → 1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-(4-methylpiperazin-1-yl)pyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

HRID 217826Notes

Reaction equation

HRID 217826 reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([N:10]=[C:11]=[O:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:19][C:20]1[CH:26]=[C:25]([O:27][C:28]2[C:33]3=[N:34][CH:35]=[C:36]([N:38]4[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]4)[N:37]=[C:32]3[N:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:21]=1[NH2:22]>>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:22][C:21]2[CH:23]=[CH:24][C:25]([O:27][C:28]3[C:33]4[C:32](=[N:37][C:36]([N:38]5[CH2:39][CH2:40][N:41]([CH3:44])[CH2:42][CH2:43]5)=[CH:35][N:34]=4)[N:31]=[CH:30][CH:29]=3)=[CH:26][C:20]=2[F:19])=[O:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 110967603-tert-Butyl-5-isocyanato-1-phenyl-1H-pyrazoleHCID 469017612-Fluoro-4-(3-(4-methylpiperazin-1-yl)pyrido[3,2-b]pyrazin-8-yloxy)aniline

Product 1

HCID 441333611-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-(4-methylpiperazin-1-yl)pyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

Procedure

Method F3 was used with 3-tert-butyl-5-isocyanato-1-phenyl-1H-pyrazole and 2-fluoro-4-(3-(4-methylpiperazin-1-yl)pyrido[3,2-b]pyrazin-8-yloxy)aniline to give the title compound as a cream-colored solid. Yield: 44 mg (77%).

Sources & evidence

ORD record
ord-149635a609d24999ab2ecdc4e8f76cab
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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