Diisopropylethylamine → HCID 86663355, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-methyl-1-[(3S)-pyrrolidin-3-yl]propan-1-amine (310 mg, 1.98 mmol), 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile (378.7 mg, 1.98 mmol) and DIPEA (512.6 mg, 690.8 μL, 3.97 mmol) in NMP (3 mL) was heated at 130° C. for 20 minutes under microwave conditions. After this time, the reaction mixture was allowed to cool to ambient temperature and diluted with EtOAc, water and saturated aqueous NaHCO3. The organic layer was separated and washed with brine, dried (Na2SO4), filtered and concentrated in vacuo. The crude mixture was purified by column chromatography (ISCO Companion™, 40 g column, eluting with MeOH/DCM) to give the sub title compound as an oil (506.3 mg, 86% Yield).

Provenance & Evidence