Morpholine → 3-Morpholinylpropylphthalimide

HRID 21784Notes

Reaction equation

HRID 21784 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:15]=[CH:14][CH:13]=[C:7]2[C:8]([NH:10][C:11](=[O:12])[C:6]=12)=[O:9].[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(OCC)C>[N:16]1([CH2:2][CH2:3][CH2:4][C:5]2[CH:15]=[CH:14][CH:13]=[C:7]3[C:8]([NH:10][C:11](=[O:12])[C:6]=23)=[O:9])[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 21958088Bromopropylphthalimide

Product 1

HCID 1317183813-Morpholinylpropylphthalimide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3-Bromopropylphthalimide (536 mg; 2.0 mmoles) and morpholine (0.35 ml; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). Reaction times and process as per Example 1.

Workup

  1. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-1c242765d39045b8814fb4299f295c90
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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