2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → HCID 44132691, compound

HRID 217845Notes

Reaction equation

HRID 217845 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[C:12]3=[N:13][CH:14]=[C:15]([N:17]([CH3:19])[CH3:18])[N:16]=[C:11]3[N:10]=[CH:9][CH:8]=2)=[CH:4][C:3]=1[F:22].[F:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][C:25]=1[N:34]=[C:35]=[O:36]>>[CH3:19][N:17]([CH3:18])[C:15]1[N:16]=[C:11]2[N:10]=[CH:9][CH:8]=[C:7]([O:6][C:5]3[CH:20]=[CH:21][C:2]([NH:1][C:35]([NH:34][C:25]4[CH:26]=[C:27]([C:30]([F:31])([F:33])[F:32])[CH:28]=[CH:29][C:24]=4[F:23])=[O:36])=[C:3]([F:22])[CH:4]=3)[C:12]2=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 46901902HCID 46901902, compound

Product 1

HCID 44132691HCID 44132691, compound

Procedure

Method F2 was used with 8-(4-amino-3-fluorophenoxy)-N,N-dimethylpyrido[3,2-b]pyrazin-3-amine and 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene to afford the title compound as a white solid. Yield: 40 mg (66%).

Sources & evidence

ORD record
ord-a67df822d6444a679615920d793f1d76
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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