3-tert-Butyl-5-isocyanato-1-phenyl-1H-pyrazole → HCID 44132693, compound

HRID 217846Notes

Reaction equation

HRID 217846 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[C:12]3=[N:13][CH:14]=[C:15]([N:17]([CH3:19])[CH3:18])[N:16]=[C:11]3[N:10]=[CH:9][CH:8]=2)=[CH:4][C:3]=1[F:22].[C:23]([C:27]1[CH:31]=[C:30]([N:32]=[C:33]=[O:34])[N:29]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[N:28]=1)([CH3:26])([CH3:25])[CH3:24]>>[C:23]([C:27]1[CH:31]=[C:30]([NH:32][C:33]([NH:1][C:2]2[CH:21]=[CH:20][C:5]([O:6][C:7]3[C:12]4=[N:13][CH:14]=[C:15]([N:17]([CH3:18])[CH3:19])[N:16]=[C:11]4[N:10]=[CH:9][CH:8]=3)=[CH:4][C:3]=2[F:22])=[O:34])[N:29]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[N:28]=1)([CH3:26])([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 110967603-tert-Butyl-5-isocyanato-1-phenyl-1H-pyrazoleHCID 46901902HCID 46901902, compound

Product 1

HCID 44132693HCID 44132693, compound

Procedure

Method F2 was used with 8-(4-amino-3-fluorophenoxy)-N,N-dimethylpyrido[3,2-b]pyrazin-3-amine and 3-tert-butyl-5-isocyanato-1-phenyl-1H-pyrazole to give the product as a light yellow solid. Yield: 65 mg (90%).

Sources & evidence

ORD record
ord-ab7b1ec02f504f1e8e0ff15a3888416c
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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