Methyl 3-(4,4-difluorocyclohexyl)-4-nitrobutanoate → 4-(4,4-Difluorocyclohexyl)pyrrolidin-2-one

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Reaction Conditions

Reaction Steps

Methyl 3-(4,4-difluorocyclohexyl)-4-nitrobutanoate a1-20 (1.390 g, 5.24 mmol, 1 eq) is dissolved in methanol (35 ml) and Raney Nickel (50% in water, 200 mg, 1.7 mmol, 0.3 eq) is rinsed 3 times with methanol and added to the solution. The mixture is heated overnight at 50° C. under a H2 atmosphere (20 bars). The mixture is then filtered and the filtrate is evaporated under reduced pressure to afford 4-(4,4-difluorocyclohexyl)pyrrolidin-2-one a1-26.

Provenance & Evidence