反应详情

Dess Martin periodinane (3.36 g, 7.91 mmol, 1.3 eq) is added portionwise under stirring to 1-[2-(2-hydroxyethyl)phenyl]piperidin-2-one a2-2 (1.33 g, 6.09 mmol, 1 eq) in dichloromethane (40 ml). After a few hours additional Dess Martin periodinane (1.29 g, 3.04 mmol, 0.5 eq) is added and the reaction mixture is stirred overnight at room temperature, then filtrated and evaporated to dryness to afford crude [2-(2-oxopiperidin-1-yl)phenyl]acetaldehyde a3-1, which is used in the next step without any further purification.

1. filtrationfiltrated
2. customevaporated to dryness