Formaldehyde → HCID 89500552, compound

Participants

Reaction Conditions

Reaction Steps

1-[2-(2-{[(Trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one a5-1 (912 mg, 3 mmol, 1 eq) is slowly added at −10° C. to a solution of methanol (220 μl, 5.4 mmol, 1.8 eq) and aqueous formaldehyde (37%, 600 μl). The reaction mixture is stirred at 0° C. for 1 h. Potassium carbonate (2 g) is added and the mixture is stirred 1 h at 0° C. Dichloromethane (15 ml) is added, the mixture obtained is dried over MgSO4, filtered, and the filtrate is concentrated under vacuum to afford 2.34 g of 1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one a5-2.

Provenance & Evidence