Sodium Hydroxide → HCID 89500600, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}piperidin-3-yl)benzoate a6-1 (0.35 g, 0.84 mmol, 1 eq) is dissolved in methanol (5 ml). NaOH 5N (0.84 ml, 4.20 mmol, 5 eq) is added and the mixture is heated at 80° C. for 16 h. The reaction mixture is concentrated under reduced pressure and the residue obtained is taken up in MeOH, filtered, and evaporated to afford 0.34 g of crude 2-(1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}piperidin-3-yl)benzoic acid a6-5 which is used in the next step without further purification.

Provenance & Evidence