Hydrochloric Acid → HCID 67954047, compound

Participants

Reaction Steps

A solution of compound 4-C (0.764 g, 3.64 mmol) in water (7 mL) was treated with 1N HCl (7.45 mL, 7.45 mmol), and the resultant solution was filtered then frozen on a dry ice/acetone bath. The water was lyophilized away to leave a mixture of compound 4-D with lithium chloride (1.01 g, 98%) as a colorless solid, used as is in the subsequent reaction. 1H-NMR (CD3OD): δ 8.84 (d, J=7.1 Hz, 1H), 7.74-7.89 (m, 2H), 7.35-7.40 (m, 1H), 4.32-4.43 (m, 1H), 1.55 (d, J=7.3 Hz, 6H); MS: m/z 205.2 (MH+).

Provenance & Evidence