Benzenesulfonyl chloride → HCID 67954034, compound

Participants

Reaction Steps

To a solution of compound 15-B (0.563 g, 2.0 mmol) in DMF (13 mL) at 0° C. was added 60% NaH (0.096 g, 2.4 mmol) and the reaction mixture was stirred for 10 minutes. Benzenesulfonyl chloride (0.563 g, 2.4 mmol) was added and the reaction mixture was stirred at room temperature overnight. The reaction was quenched by the addition of H2O and the solution was extracted with ethyl acetate. After separation of the organic and aqueous layers a sufficient amount of water was added to remove any dissolved DMF from the organic layer. The organic layer was dried over Na2SO4, filtered, and the solvent evaporated under reduced pressure to afford the crude product. The crude material was purified by flash column chromatography, eluting with a hexanes-EtOAc gradient to give compound 15-C as a white solid (0.825 g, 86%); MS m/z (M+H+) 480.

Provenance & Evidence