Morpholine → 4-Morpholinylbutylphthalimide

HRID 21786Notes

Reaction equation

HRID 21786 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:16]=[CH:15][CH:14]=[C:8]2[C:9]([NH:11][C:12](=[O:13])[C:7]=12)=[O:10].[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>C(OCC)C>[N:17]1([CH2:2][CH2:3][CH2:4][CH2:5][C:6]2[CH:16]=[CH:15][CH:14]=[C:8]3[C:9]([NH:11][C:12](=[O:13])[C:7]=23)=[O:10])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 21960043Bromobutylphthalimide

Product 1

HCID 220025214-Morpholinylbutylphthalimide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4-Bromobutylphthalimide (564 mg; 2.0 mmoles) and morpholine (0.35 ml; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). Reaction times and process as per Example 1.

Workup

  1. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-4a65fd69586246198102dd69870cb685
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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