HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethoxy)benzoyl chloride → N-(3-(2-methyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)-3-(trifluoromethoxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethoxy)benzoyl chloride | HCID 522854 | — |
| Reactant | 8-(3-aminophenoxy)-2-methylpyrido[2,3-b]pyrazin-3(4H)-one | HCID 46901594 | — |
| Product | N-(3-(2-methyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)-3-(trifluoromethoxy)benzamide | HCID 44133723 | — |
Reaction Steps
Method G1 was used with 8-(3-aminophenoxy)-2-methylpyrido[2,3-b]pyrazin-3(4H)-one and 3-trifluoromethoxybenzoyl chloride to afford the title compound as a slightly yellow solid (74 mg, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198279B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-a78ddbb230f84f729449466a4182e12f |
| Source note | uspto-grants-2012_06 |