2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → HCID 46901423, compound

HRID 217869Notes

Reaction equation

HRID 217869 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[C:8]=2[N+:14]([O-:16])=[O:15])=[CH:4][C:3]=1[F:19].[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=1[N:31]=[C:32]=[O:33]>>[NH2:13][C:9]1[C:8]([N+:14]([O-:16])=[O:15])=[C:7]([O:6][C:5]2[CH:17]=[CH:18][C:2]([NH:1][C:32]([NH:31][C:22]3[CH:23]=[C:24]([C:27]([F:28])([F:30])[F:29])[CH:25]=[CH:26][C:21]=3[F:20])=[O:33])=[C:3]([F:19])[CH:4]=2)[CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 57974619HCID 57974619, compound

Product 1

HCID 46901423HCID 46901423, compoundYield 85%

Procedure

Using Method F2 with 4-(4-amino-3-fluorophenoxy)-3-nitropyridin-2-amine and 2-fluoro-5-trifluoromethylphenyl isocyanate, the title compound was obtained (yield 85%).

Sources & evidence

ORD record
ord-497f20707b424ff483fb2435ecf2c7b0
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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