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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2178718Generated: October 31, 2026

tert-Butyldimethylsilyl chloride → HCID 88959644, compound

https://huagongshe.com/reaction/2178718

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyldimethylsilyl chlorideHCID 28928—
Reactant1-Chloro-4-hydroxyisoquinolineHCID 4281882—
ProductHCID 88959644HCID 88959644—

Reaction Steps

1-Chloroisoquinolin-4-ol was treated with tert-butyldimethylsilyl chloride to produce 4-{[tert-butyl(dimethyl)silyl]oxy}-1-chloroisoquinoline. Halogen exchange gave 4-{[tert-butyl(dimethyl)silyl]oxy}-1-iodoisoquinoline, which was treated with copper iodide and methyl difluoro(fluorosulfonyl)acetate to produce 1-(trifluoromethyl)isoquinolin-4-ol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09067934B2
Source datasetuspto-grants-2015_06
ORD IDord-516178d10cf1454b9c0266623d7deeb3
Source noteuspto-grants-2015_06