HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59212645, compound → HCID 59212647, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59212645 | HCID 59212645 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 59212647 | HCID 59212647 | 152.9% |
Reaction Steps
tert-Butyl 4-methyl-4-{(3S)-3-methyl-4-[6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl}piperidine-1-carboxylate (0.32 g, 0.6 mmol) was dissolved in a 4 M solution of HCl in dioxane (8.0 mL). After being stirred at room temperature for 2 hrs, the solution was concentrated to give the title compound (0.35 g) as a trihydrochloride salt. MS calculated for C21H30F3N3: (M+H)+382; found 382.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067921B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-32cefa5116fa47edb87640c14f2bfb59 |
| Source note | uspto-grants-2015_06 |