HRID217878

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11401974

5-Amino-3-tert-butyl-1-(2-methylpyridine-5-yl)pyrazole

C13H18N4

结构：O=C(Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)Oc1ccccc1

HCID59588837

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)cn1

HCID59588860

未命名化合物

收率 17%

PROCEDURE

实验过程

Method F4 was used with 65 mg (0.17 mmol) of phenyl 2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenylcarbamate and 45 mg (0.2 mmol) of 3-tert-butyl-1-(6-methylpyridin-3-yl)-1H-pyrazol-5-amine (Regan, J. et al., J. Med. Chem. 2002, 45, 2994-3008). Obtained 15 mg, 17% yield of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e972cf2e8b6d41fea49370d0ca5a017f
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08198279B2
来源说明: uspto-grants-2012_06

反应 SMILES

[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[C:14]3[N:15]=[CH:16][C:17](=[O:19])[NH:18][C:13]=3[N:12]=[CH:11][CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:20][C:21](=[O:29])OC1C=CC=CC=1.[C:30]([C:34]1[CH:38]=[C:37]([NH2:39])[N:36]([C:40]2[CH:41]=[N:42][C:43]([CH3:46])=[CH:44][CH:45]=2)[N:35]=1)([CH3:33])([CH3:32])[CH3:31]>>[C:30]([C:34]1[CH:38]=[C:37]([NH:39][C:21]([NH:20][C:3]2[CH:4]=[CH:5][C:6]([O:8][C:9]3[C:14]4[N:15]=[CH:16][C:17](=[O:19])[NH:18][C:13]=4[N:12]=[CH:11][CH:10]=3)=[CH:7][C:2]=2[F:1])=[O:29])[N:36]([C:40]2[CH:41]=[N:42][C:43]([CH3:46])=[CH:44][CH:45]=2)[N:35]=1)([CH3:33])([CH3:32])[CH3:31]