Ethyl 3-(4-pyridyl)-3-oxopropionate → (+/-)2-(4-Oxo-2-pyridin-4-yl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl)-isoindole-1,3-dione

HRID 217889Notes

Reaction equation

HRID 217889 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9]([O:11]CC)=O)=[CH:3][CH:2]=1.[NH2:15][C:16]1[CH:20]([N:21]2[C:29](=[O:30])[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[C:22]2=[O:31])[CH2:19][CH2:18][N:17]=1>>[O:11]=[C:9]1[N:17]2[CH2:18][CH2:19][CH:20]([N:21]3[C:29](=[O:30])[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[C:22]3=[O:31])[C:16]2=[N:15][C:7]([C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)=[CH:8]1

Participants

3

Reactant 2

HCID 2735202Ethyl 3-(4-pyridyl)-3-oxopropionateHCID 672657232-(2-amino-4,5-dihydro-3H-pyrrol-3-yl)-isoindole-1,3-dione

Product 1

HCID 67265629(+/-)2-(4-Oxo-2-pyridin-4-yl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl)-isoindole-1,3-dione

Procedure

By analogy with the method described in example 1 (step 1.3), using ethyl 3-(4-pyridinyl)-3-oxopropionate (prepared by analogy to the method described in patent DE 2705582) and using 2-(2-amino-4,5-dihydro-3H-pyrrol-3-yl)-isoindole-1,3-dione, the compound was obtained as a white powder.

Workup

  1. customprepared by analogy to the method
  2. customthe compound was obtained as a white powder

Sources & evidence

ORD record
ord-ee0f291082e042efbfc7249690a22a7b
Source dataset
uspto-grants-2012_06
Patent number
US08198287B2

Reaction notes

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