2-(4,6-Dichloro-1,5-naphthyridin-3-yl)-2-oxoethyl acetate → HCID 178476434, compound

HRID 2178930Notes

Reaction equation

HRID 2178930 reaction equation
[C:1]([O:4][CH2:5][C:6]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1Cl)=[N:15][C:14]([Cl:19])=[CH:13][CH:12]=2)=[O:7])(=[O:3])[CH3:2].[CH3:20][N:21]([CH2:23][C@H:24]1[CH2:29][CH2:28][C@H:27]([NH2:30])[CH2:26][CH2:25]1)[CH3:22]>>[C:1]([O:4][CH2:5][C:6]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[NH:30][C@H:27]1[CH2:28][CH2:29][C@H:24]([CH2:23][N:21]([CH3:22])[CH3:20])[CH2:25][CH2:26]1)=[N:15][C:14]([Cl:19])=[CH:13][CH:12]=2)=[O:7])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 897051652-(4,6-Dichloro-1,5-naphthyridin-3-yl)-2-oxoethyl acetateHCID 178483674HCID 178483674, compound

Product 1

HCID 178476434HCID 178476434, compoundYield 65.1%

Procedure

Following general procedure I, 2-(4,6-dichloro-1,5-naphthyridin-3-yl)-2-oxoethyl acetate (101 mg, 0.33 mmol) was reacted with trans-4-[(dimethylamino)methyl]cyclohexan amine (67 mg, 0.43 mmol) to afford the desired product (90 mg, 65%) as an off-white solid.

Sources & evidence

ORD record
ord-d11cdfab8ca0477082bb52461d0dbb59
Source dataset
uspto-grants-2015_06
Patent number
US09067937B2

Reaction notes

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