Cyclobutyl(4,6-dichloro-1,5-naphthyridin-3-yl)methanone → (6-Chloro-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)(cyclobutyl)methanone

HRID 2178971Notes

Reaction equation

HRID 2178971 reaction equation
[CH:1]1([C:5]([C:7]2[CH:8]=[N:9][C:10]3[C:15]([C:16]=2Cl)=[N:14][C:13]([Cl:18])=[CH:12][CH:11]=3)=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH3:19][N:20]([CH2:22][C@H:23]1[CH2:28][CH2:27][C@H:26]([NH2:29])[CH2:25][CH2:24]1)[CH3:21]>>[Cl:18][C:13]1[N:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:5]([CH:1]1[CH2:4][CH2:3][CH2:2]1)=[O:6])=[C:16]2[NH:29][CH:26]1[CH2:27][CH2:28][CH:23]([CH2:22][N:20]([CH3:21])[CH3:19])[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 117773435Cyclobutyl(4,6-dichloro-1,5-naphthyridin-3-yl)methanoneHCID 178483674HCID 178483674, compound

Product 1

HCID 117774246(6-Chloro-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)(cyclobutyl)methanone

Procedure

(6-Chloro-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)(cyclobutyl)methanone was prepared with conditions described in Example 131 using cyclobutyl(4,6-dichloro-1,5-naphthyridin-3-yl)methanone and trans-4-((dimethylamino)methyl)cyclohexanamine.

Sources & evidence

ORD record
ord-8841ab203db84775b6b6b6f6e886f04c
Source dataset
uspto-grants-2015_06
Patent number
US09067937B2

Reaction notes

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