関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | methyl 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate | HCID 5061470 | — |
| 反応物 | Ethanol tetrahydrofuran water | HCID 18504229 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4H,5H,6H-cyclopenta(b)thiophene-2-carboxylic acid | HCID 770980 | 91% |
反応手順
To a solution of methyl 4H,5H,6H-cyclopenta[b]thiophene-2-carboxylate (1 g, 5.49 mmol, 1.00 equiv) in a THF/EtOH/water (10/10/10 mL) mixture was added LiOH (660 mg) at room temperature. The resulting solution was stirred for 3 h at 50° C. in an oil bath and then diluted with 20 mL of water. The pH value of the solution was adjusted to 5 with 2 M aqueous hydrochloric acid. The precipitate was collected by filtration and dried in an oven under reduced pressure to give the desired 4H,5H,6H-cyclopenta[b]thiophene-2-carboxylic acid (0.84 g, 91%) as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09067948B2 |
|---|
| 出典データセット | uspto-grants-2015_06 |
|---|
| ORD ID | ord-a57f410a6c644dd7a15ad29246d692f8 |
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| 出典メモ | uspto-grants-2015_06 |
|---|
