Benzoyl Peroxide → HCID 69023349, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.080 g (0.24 mmol) of (4-oxo-2-pyrimidin-4-yl -4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepin-10-yl)-carbamic acid ethyl ester in dimethylformamide (4 mL) were added 0.21 g (1.21 mmol) of N-bromosuccinimide and 0.03 g (0.12 mmol) of benzoyl peroxide. The solution was stirred at room temperature for 10 min and at 50° C. for 20 min. The reaction was quenched by adding a saturated solution of ammonium chloride. The product was extracted with dichloromethane, the organic phase was washed with a saturated solution of sodium chloride, dried over sodium sulfate, filtered and the solvent was evaporated. The residue was chromatographed on silica gel eluting with a mixture of dichloromethane/methanol in the proportions 95/5 to afford 58 mg of a solid.

Provenance & Evidence