2-Bromoethyl methyl ether → 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-(2-methoxy-ethyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine

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Reaction Steps

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine (example 3, step b), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 1-bromo-2-methoxyethane and isolated as light-yellow gum (4.5 mg, 32%). MS (m/e): 341.3 (MH+).

Provenance & Evidence