Hydrogen Bromide → HCID 69024687, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.34 g (0.84 mmol) of (+/−)(3-bromo-4-oxo-2-pyrimidin-4-yl-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepin-10-yl)-carbamic acid ethyl ester in 2 mL of acetic acid was added 0.78 mL (4.21 mmol) of a solution of hydrobromic acid (5.7N in acetic acid). The reaction was stirred at 100° C. for 3 h. The solvent was evaporated and an acid-basic work-up gave 65 mg (33%) of 10-amino-3-bromo-2-pyrimidin-4-yl-7,8,9,10-tetrahydro-6H-pyrimido[1,2-a]azepin-4-one as an orange oil. The compound was used as such in the next step.

Provenance & Evidence