Diisopropylethylamine → HCID 89586134, compound

Participants

Reaction Steps

A mixture of 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine (11.6 mg, 41.1 μmol), 2-bromo-1-(2-chlorophenyl)ethanone (11.5 mg, 7.19 μl, 49.3 μmol) and DIPEA (10.6 mg, 14.4 μl, 82.2 μmol) were combined with DCM (250 μl) to give a light yellow solution. The reaction mixture was stirred at r.t. for 4 h and purified by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and NEt3. The product containing fractions were evaporated to yield 1.9 mg (11%) of the title compound as yellow gum. MS (m/e): 435.3 (MH+).

Provenance & Evidence