2-Bromo-3'-chloroacetophenone → HCID 71575797, compound

HRID 2179042Notes

Reaction equation

[C:1]([C:5]1[N:6]=[C:7]([N:24]2[CH2:28][CH2:27][C:26]([F:30])([F:29])[CH2:25]2)[C:8]2[C:9](=[N:11][N:12]([CH2:14][C:15](C3C=CC=CC=3Cl)=[O:16])[N:13]=2)[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C(C1N=C(N2CCC(F)(F)C2)C2N=NNC=2N=1)(C)(C)C.BrCC([C:55]1[CH:60]=[CH:59][CH:58]=[C:57]([Cl:61])[CH:56]=1)=O>>[C:1]([C:5]1[N:6]=[C:7]([N:24]2[CH2:28][CH2:27][C:26]([F:29])([F:30])[CH2:25]2)[C:8]2[C:9](=[N:11][N:12]([CH2:14][C:15]([C:55]3[CH:60]=[CH:59][CH:58]=[C:57]([Cl:61])[CH:56]=3)=[O:16])[N:13]=2)[N:10]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

Reactant 3

HCID 387382-Bromo-3'-chloroacetophenone

HCID 89586134HCID 89586134, compound

HCID 178441789HCID 178441789, compound

Product 1

HCID 71575797HCID 71575797, compound

Procedure

In analogy to the procedure described for the synthesis of 2-[5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl]-1-(2-chloro-phenyl)-ethanone (example 47), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 2-bromo-1-(3-chlorophenyl)ethanone and isolated as yellow solid. MS (m/e): 435.3 (MH+).

Workup

customisolated as yellow solid

Sources & evidence

ORD record: ord-ed046513c1704ee7b55f0b24194f0c2d
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09067943B2

Reaction notes

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