5-(chloromethyl)-1-methyl-1H-1,2,3-triazole hydrochloride → 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-(3-methyl-3H-[1,2,3]triazol-4-ylmethyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine

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Reaction Steps

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine (example 3, step b), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 5-(chloromethyl)-1-methyl-1H-1,2,3-triazole hydrochloride and isolated as light yellow solid. MS (m/e): 378.3 (MH+).

Provenance & Evidence