5-(chloromethyl)-1-methyl-1H-1,2,3,4-tetrazole → HCID 89586367, compound

HRID 2179107Notes

Reaction equation

HRID 2179107 reaction equation
C([C:5]1N=C(N2CCC(F)(F)C2)[C:8]2[C:9](=[N:11][N:12](CC)[N:13]=2)[N:10]=1)(C)(C)C.[F:23][C:24]1([F:44])[CH2:28][CH2:27][N:26]([C:29]2[C:30]3[N:43]=[N:42][NH:41][C:31]=3[N:32]=[C:33]([O:35][CH2:36][C:37]([CH3:40])([CH3:39])[CH3:38])[N:34]=2)[CH2:25]1.ClCC1N(C)N=NN=1>>[F:44][C:24]1([F:23])[CH2:28][CH2:27][N:26]([C:29]2[C:30]3[C:31](=[N:41][N:42]([CH2:8][C:9]4[N:10]([CH3:5])[N:13]=[N:12][N:11]=4)[N:43]=3)[N:32]=[C:33]([O:35][CH2:36][C:37]([CH3:38])([CH3:39])[CH3:40])[N:34]=2)[CH2:25]1

Participants

4

Reactant 3

HCID 122050865-(chloromethyl)-1-methyl-1H-1,2,3,4-tetrazoleHCID 715763075-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 178446998HCID 178446998, compound

Product 1

HCID 89586367HCID 89586367, compound

Procedure

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine (example 3, step b), the title compound was prepared from 7-(3,3-Difluoro-pyrrolidin-1-yl)-5-(2,2-dimethyl-propoxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 5-(chloromethyl)-1-methyl-1H-tetrazole. MS (m/e): 409.4 (MH+).

Sources & evidence

ORD record
ord-aa15f4d4fa49484980384715ef06f114
Source dataset
uspto-grants-2015_06
Patent number
US09067943B2

Reaction notes

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