HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(chloromethyl)-1-methyl-1H-1,2,3,4-tetrazole → HCID 86296050, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(chloromethyl)-1-methyl-1H-1,2,3,4-tetrazole | HCID 12205086 | — |
| Reactant | 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71576307 | — |
| Reactant | (R)-1-(3-Benzyl-5-tert-butyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-pyrrolidin-3-ol | HCID 86683386 | — |
| Reactant | HCID 178441790 | HCID 178441790 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 86296050 | HCID 86296050 | — |
Reaction Steps
(R)-1-(3-Benzyl-5-tert-butyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-pyrrolidin-3-ol was hydrogenated over Pd/C and the resulting (R)-1-(5-tert-Butyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-pyrrolidin-3-ol was reacted in analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine (example 3, step b) with 5-(chloromethyl)-1-methyl-1H-tetrazole. MS (m/e): 359.3 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067943B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-c9141f036afb4803aac2b92aa30d9e11 |
| Source note | uspto-grants-2015_06 |