alpha-Bromo-o-chlorotoluene → HCID 89586594, compound

HRID 2179120Notes

Reaction equation

HRID 2179120 reaction equation
C(C1N=C(N2CCC(F)(F)C2)C2C(=NN(CC)N=2)N=1)(C)(C)C.[C:23]([NH:27][C:28]1[N:29]=[C:30]([N:37]2[CH2:41][CH2:40][C@H:39]([NH:42][C:43](=[O:45])[CH3:44])[CH2:38]2)[C:31]2[N:36]=[N:35][NH:34][C:32]=2[N:33]=1)([CH3:26])([CH3:25])[CH3:24].Br[CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=1[Cl:54]>>[C:23]([NH:27][C:28]1[N:29]=[C:30]([N:37]2[CH2:41][CH2:40][C@H:39]([NH:42][C:43](=[O:45])[CH3:44])[CH2:38]2)[C:31]2[C:32](=[N:34][N:35]([CH2:47][C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=3[Cl:54])[N:36]=2)[N:33]=1)([CH3:26])([CH3:24])[CH3:25]

Participants

4

Reactant 3

HCID 11905alpha-Bromo-o-chlorotolueneHCID 715763075-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 178475049HCID 178475049, compound

Product 1

HCID 89586594HCID 89586594, compound

Procedure

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine (example 3, step b), the title compound was prepared from N—[(S)-1-(5-tert-Butylamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-pyrrolidin-3-yl]-acetamide and 1-(bromomethyl)-2-chlorobenzene. MS (m/e): 443.4 (MH+).

Sources & evidence

ORD record
ord-49e97adaab0e4268bfcd028d59155c3f
Source dataset
uspto-grants-2015_06
Patent number
US09067943B2

Reaction notes

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