Diethyl Ether → HCID 86709917, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of benzoyl chloride (10.90 mL, 94.60 mmol) in ether (250 mL) and water (150 mL) was cooled over ice. Potassium carbonate (14.62 g, 105.78 mmol) was added followed by drop wise addition of cyclobutylamine (6.00 mL, 70.28 mmol). The ice was removed and the mixture stirred at 25° C. for 48 hours. DCM (350 mL) was added and the mixture washed with water (2×250 mL). The aqueous was back extracted with DCM (2×150 mL). The combined organic extracts were dried over MgSO4, filtered and evaporated to dryness under reduced vacuum to afford the crude N-(cyclobutyl)benzamide (12.14 g, 69.26 mmol, 98.6% yield) which was used directly in the next reaction.

Provenance & Evidence