Morpholine → 6-Morpholinylhexylphthalimide

HRID 21792Notes

Reaction equation

HRID 21792 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][CH:16]=[C:10]2[C:11]([NH:13][C:14](=[O:15])[C:9]=12)=[O:12].[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>C(OCC)C>[N:19]1([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]2[CH:18]=[CH:17][CH:16]=[C:10]3[C:11]([NH:13][C:14](=[O:15])[C:9]=23)=[O:12])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 219308536-Bromohexylphthalimide

Product 1

HCID 1317183836-Morpholinylhexylphthalimide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

6-Bromohexylphthalimide (633 mg; 2.0 mmoles) and morpholine (0.35 mg; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). Reaction times and process as per Example 1.

Workup

  1. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-a6672e342e394ba3843c42e42e9f6a38
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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