Hydrochloric Acid → HCID 57414387, compound

Participants

Reaction Steps

2-Methyl-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine (13 mg, 0.04 mmol) was treated with 1.25M HCl in methanol (3 mL). After 10 min the solution was concentrated in vacuo to give 2-methyl-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (18 mg, 90%, AUC HPLC 96.8%) as an off-white solid: mp 272° C. 1H NMR (DMSO-d6, 300 MHz) δ 11.16 (s, 1H), 8.35 (d, J=1.8 Hz, 1H), 7.99-7.95 (m, 2H), 7.92 (dd, J=8.7, 1.8 Hz, 1H), 7.84 (d, J=8.7 Hz, 1H), 7.71-7.59 (m, 3H), 4.65 (br s, 1H), 4.36 (br s, 1H), 3.78 (br s, 1H), 3.57 (br s, 1H), 3.21 (br s, 2H), 2.95 (s, 3H); ESI MS m/z 328 [M+H]+.

Provenance & Evidence