反应详情

The product of Example 29, step B and sodium 4-fluorobenzenesulfinate were coupled using the procedure of Example 29, step C. Purification by flash column chromatography (SiO2, 75:25 hexane/ethyl acetate) provided tert-butyl 8-(4-fluorophenylsulfonyl)-3,4-dihydrobenzofuro[3,2-c]pyridine-2(1H)-carboxylate (217 mg, 36%) as a pale yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.07 (s, 1H), 8.01-7.91 (m, 2H), 7.81 (dd, J=8.7, 1.8 Hz, 1H), 7.52 (d, J=8.4 Hz, 1H), 7.22-7.11 (m, 2H), 4.57 (s, 2H), 3.89-3.76 (m, 2H), 2.92-2.80 (m, 2H), 1.51 (s, 9H).

1. customPurification by flash column chromatography (SiO2, 75:25 hexane/ethyl acetate)