Hydrochloric Acid → 8-(4-Fluorophenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride

Participants

Reaction Steps

The product of step B (60 mg, 0.10 mmol) was converted to hydrochloride salt by dissolving in methanol and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give 8-(4-fluorophenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (60 mg, 90%, AUC HPLC>99%) as a white solid: mp 270-280° C. <<MP data>>; 1H NMR (CD3OD, 300 MHz) δ 8.27 (d, J=1.8 Hz, 1H), 8.10-8.00 (m, 2H), 7.95 (dd, J=8.7, 2.1 Hz, 1H), 7.71 (d, J=8.7 Hz, 1H), 7.36-7.25 (m, 2H), 4.81 (t, J=1.5 Hz, 2H), 3.69 (t, J=6.0 Hz, 2H), 3.24-3.16 (m, 2H); APCI MS m/z 332 [M+H]+.

Provenance & Evidence