Sodium 4-chlorobenzenesulfinate → HCID 68109196, compound

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Reaction Steps

The product of Example 29, step B and sodium 4-chlorobenzenesulfinate were coupled using the procedure of Example 29, step C. Purification by flash column chromatography (SiO2, 85:15 hexane/ethyl acetate) provided tert-butyl 8-(4-chlorophenylsulfonyl)-3,4-dihydrobenzofuro[3,2-c]pyridine-2(1H)-carboxylate (118 mg, 37%) as a yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.06 (s, 1H), 7.92-7.85 (m, 2H), 7.80 (dd, J=8.7, 1.8 Hz, 1H), 7.51 (d, J=8.7 Hz, 1H), 7.49-7.43 (m, 2H), 4.57 (s, 2H), 3.83 (t, J=5.4 Hz, 2H), 2.92-2.81 (m, 2H), 1.51 (s, 9H).

Provenance & Evidence